Do you suffer from the following Symptoms?

  • Fatigue
  • Depression
  • Thyroid disorders
  • Irritability
  • Substance addiction
  • Social withdrawal
  • Obesity
  • Heart disease


In previous weeks we have investigated various nutritional pathways and their effect on mental health. This week we will look at another phenomenon which is occurring in your body as we speak: methylation. Methylation has an impact on the cardiovascular system, the immune system, and as we will now see, mental health. 

Why it matters

Methylation is not a condition to be treated, but an essential, complex and crucial pathway to be understood. Patients may have a variety of dysfunctions in this pathway and the more a clinician understands the patient’s case and their dysfunction, the better outcome.

Methylation is a complex pathway, often called “the crossroads of metabolism” and has a subtle yet real impact on your health

Innovative pathology testing

Having worked in health food and pharmacy some time, supplement sales certainly increasing. While this is not always a bad thing, self prescribed supplements may:

1) Be a waste of money due to clear no need for that nutrient

2) Possibly become toxic; Iron or Zinc being just two examples

Testing the methylation pathway can lead to a more focused treatment that lead to better results and also less money spent in the long term.

Functional pathology testing helps focus your treatment

Related: buying supplements vs naturopathic consultation

How methylation impacts your health

The major pathway in methylation is the “methionine pathway”. Simply, the amino acid homocysteine is converted to SAMe and then back to homocysteine. Homocysteine is a marking for heart disease, and too much can damage the nervous system and DNA.  Also, Dysfunction in this pathway can lead to lack of SAMe; a natural anti-depressant compound.

Poor methylation may lead to nervous system damage and mild depression

Some new small studies have sighted Folates role in lifting mood. Due to a gene mutation, Folate may not biologically active meaning its not, ‘body ready’. Up to 30% of the population have this gene malfunction in various degress. 

Conditions associated with this are:


As mentioned, this is related to high levels of homocysteine, and consequently, low SAMe, resulting in depression, anxiety and fatigue.


Some small but growing information shows an increased risk of Autism Spectrum Disorder (ASD) associated with MTFHR gene mutation. A simple swab test can be one piece of information used to guide nutrient choice.


Other conditions impacted by methylation include;

  • Obesity 
  • Coronary artery disease
  • Infertility

What can I take from this?

If you have tried various approaches to mental health and are seeking a rational yet natural approach to your health, consider dropping in to discuss your options. While testing is not essential, it can assist. Please note that we are not diagnosing, but looking to understanding pathways in the body that in long term, lead to poor health and possible diagnosis.

Click here to book in today

Supporting Evidence: 

Wardle, J., & Sarris, J. (2014). Clinical Naturopathy. Sydney, Churchill Livingstone/Elsevier.

Hechtman, L. (2012). Clinical Naturopathic medicine. Sydney, Australia: Churchill Livingstone/Elsevier Australia.